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Furthermore, as a hallmark of the aging population, m -Dys could onset chronic inflammation with massive cytokine release and cause multi-organ failure with fatal outcomes in elderly COVID-19 patients 177

Subsequent frameworks, the 2007 National Institute for Health and Care Excellence (NICE) criteria [21] and 2015 Institute of Medicine (IOM) criteria [22] further refined and updated the diagnostic approach

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Sarcomere disruption is more evident in patients with moderate and severe COPD(Orozco-Levi et al., 2001)